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Acting as an NMDA antagonist can be just one system by which methadone decreases craving for opioids and tolerance, and has been proposed for a possible mechanism for its distinguished efficacy regarding the cure of neuropathic agony.[citation necessary] Methadone also acted being a powerful, noncompetitive αthreeβ4 neuronal nicotinic acetylcholine receptor antagonist in rat receptors, expressed in human embryonic kidney cell strains.[62]

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Check patients with chance components for enhancement of prolonged QT interval, a historical past of cardiac conduction abnormalities, and those getting prescription drugs impacting cardiac conduction.

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